Anti-FGF3 Antilichaam

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene. The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.

Boster Bio Anti-FGF3 Antibody Picoband® catalog # A03316-2. Tested in ELISA, IHC applications. This antibody reacts with Human.

Glutathione S-transferase Mu 3; GST class-mu 3; GSTM3-3; hGSTM3-3; GSTM3; GST5

FGF3

2248

P11487

Human

No cross-reactivity with other proteins.

E.coli-derived human FGF3 recombinant protein (Position: A18-H239) .

Testis and brain.

IHC, ELISA

Cancer, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

1. Alsmadi, O., Meyer, B. F., Alkuraya, F, Wakil, S., Alkayal, F., Al-Saud, H., Ramzan, K., Al-Sayed, M. Syndromic congenital sensorineural deafness, microtia and microdontia resulting from a novel homoallelic mutation in fibroblast growth factor 3 (FGF3) . Europ. J. Hum. Genet. 17: 14-21, 2009. 2. Brookes, S., Smith, R., Casey, G., Dickson, C., Peters, G. Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells. Oncogene 4: 429-436, 1989. 3. Casey, G., Smith, R., McGillivray, D., Peters, G., Dickson, C. Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene. Molec. Cell. Biol. 6: 502-510, 1986.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A03316-2

33 kDa

Glutathione S-transferase mu 3

Cytoplasm.

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.