Anti-FGFR2 Antibody Picoband® 0,00647 Vervoeging

Fibroblast growth factor receptor 2 (FGFR2) is a receptor for fibroblast growth factor encoded on a gene residing on chromosome 10. FGFR2 has also been designated as CD332. FGFR2 is a membrane-spanning tyrosine kinase that serves as a high affinity receptor for several members of the fibroblast growth factor (FGF) family. Its signals are absolutely required for vertebrate limb induction and that an FGFR2 signal is essential for the reciprocal regulation loop between FGF8 and FGF10 during limb induction. FGFR2 contributes to the outgrowth, differentiation, and maintenance of the inner cell mass and raise the possibility that this activity is mediated by FGF4 signals transmitted by FGFR2. The role of early FGF signaling in pregastrulation development as a possible adaptation to mammalian (amniote) embryogenesis is discussed.

Interleukin-4; IL-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; Lymphocyte stimulatory factor 1; Pitrakinra; IL4

FGFR2

2263

P21802

Human

No cross-reactivity with other proteins.

E.coli-derived human FGFR2 recombinant protein (Position: R22-E368) .

Highly expressed in metastatic colon tumors. Expressed in primary colon tumors. Weakly expressed in normal colon tissue.

Flow Cytometry

Adaptive Immunity, Cancer, Cytokines, Immunology, Innate Immunity, Interleukins, Tumor Immunology

Immunogen affinity purified.

Liquid

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727) . It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity) .

1. Xu, X.; Weinstein, M.; Li, C.; Naski, M.; Cohen, R. I.; Ornitz, D. M.; Leder, P.; Deng, C. : Fibroblast growth factor receptor 2 (FGFR2) -mediated reciprocal regulation loop between FGF8 and FGF10 is essential for limb induction. Development 125: 753-765, 1998. 2. Arman, E.; Haffner-Krausz, R.; Chen, Y.; Heath, J. K.; Lonai, P. : Targeted disruption of fibroblast growth factor (FGF) receptor 2 suggests a role for FGF signaling in pregastrulation mammalian development. Proc. Nat. Acad. Sci. 95: 5082-5087, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

36053 MW

6

Interleukin 4

Secreted.

Glyceraldehyde-3-phosphate dehydrogenase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.