Anti-FHL2 Antibody Picoband® fluoro488 Vervoeging

Four and a half LIM domains protein 2 also known as FHL-2 is a protein that in humans is encoded by the FHL2 gene. This gene encodes a member of the four-and-a-half-LIM-only protein family. Family members contain two highly conserved, tandemly arranged, zinc finger domains with four highly conserved cysteines binding a zinc atom in each zinc finger. This protein is thought to have a role in the assembly of extracellular membranes. Also, this gene is down-regulated during transformation of normal myoblasts to rhabdomyosarcoma cells and the encoded protein may function as a link between presenilin-2 and an intracellular signaling pathway. Multiple alternatively spliced variants encoding different isoforms have been identified.

Carnitine O-palmitoyltransferase 2, mitochondrial; Carnitine palmitoyltransferase II; CPT II; CPT2; CPT1

FHL2

2274

Q14192

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human FHL2 recombinant protein (Position: T234-I279) .

Expressed mainly in adipose tissues.

Flow Cytometry

Cardiovascular, G Protein Signaling, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.

1. Amaar, Y. G., Thompson, G. R., Linkhart, T. A., Chen, S.-T., Baylink, D. J., Mohan, S. Insulin-like growth factor-binding protein 5 (IGFBP-5) interacts with a four and a half LIM protein 2 (FHL2) . J. Biol. Chem. 277: 12053-12060, 2002. 2. Bai, S., Kitaura, H., Zhao, H., Chen, J., Muller, J. M., Schule, R., Darnay, B., Novack, D. V., Ross, F. P., Teitelbaum, S. L. FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner. J. Clin. Invest. 115: 2742-2751, 2005. 3. Chan, K. K., Tsui, S. K. W., Lee, S. M. Y., Luk, S. C. W., Liew, C. C., Fung, K. P., Waye, M. M. Y., Lee, C. Y. Molecular cloning and characterization of FHL2, a novel LIM domain protein preferentially expressed in human heart. Gene 210: 345-350, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

51990 MW

6

Carnitine palmitoyltransferase 2

Mitochondrion inner membrane ; Peripheral membrane protein ; Matrix side

Angiotensinogen

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.