Anti-Fibronectine Antilichaam

In the extracellular matrix, fibronectin provides essential connections to cells through interaction with integrins and other receptors that regulate cell adhesion, migration, and differentiation. Fibronectin is secreted as a large dimeric glycoprotein with subunits that range in size from 230 kDa to 270 kDa. Fibronectin is composed of three different types of modules termed type I, II, and III repeats, as well as two fibrin binding and two heparin binding domains, a collagen interaction region and cell attachment domain. The diverse set of binding domains provides fibronectin with the ability to interact simultaneously with other fibronectin molecules, other ECM components (e.g., collagens and proteoglycans), cell surface receptors, and extracellular enzymes. Plasma fibronectin (soluble dimeric form) is secreted by hepatocytes, while cellular fibronectin (dimeric or cross-linked multimeric forms), made by fibroblasts, epithelial and other cell types, is deposited as fibrils in the extracellular matrix. Fibronectin fibrilogenesis has important functions during tissue development, and during pathological progression of tissues and wound healing.

Our Fibronectin mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Fibronectin and is protein g purified. It is great for use in ELISA, WB, ICC, IP.

Our Fibronectin mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human Fibronectin and is Protein G purified. It is great for use in WB, ICC, IP.

FN, Cold-insoluble globulin, CIG, Anastellin, Ugl-Y1, Ugl-Y2, Ugl-Y3, FN1

FN1

P02751

Human

Clone (M022) was generated from a proprietary antigen related to native human fibronectin from the MeWo melanoma cell line.

Fibronectin

M022

Unconjugated

ELISA, WB, ICC, IP

Cell Adhesion Molecules, Extracellular Matrix Proteins, Neurogenesis and Development

Protein G Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

GOmAb

250

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein G purified culture supernatant.

1:500

1:100

Clone M022 mouse monoclonal antibody detects a 250 kDa* protein on SDS-PAGE immunoblots of native or denatured human A549, MeWo, and LNCaP cells, as well as human plasma fibronectin. The antibody also works for immunoprecipitation, immunohistochemistry, and immunocytochemistry, as well as binds fibronectin in live cells and unfixed extracellular matrix.

1:100

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_3068442