Anti-FK506-bindend eiwit 15 FKBP15 Antilichaam

FKBP15, also known as FKBP133, is a member of the FK506-binding protein family, a group of proteins initially identified as immunophilins, targets for the immunosupressant drugs FK506 and Rapamycin. FKBP15 is expressed in the developing nervous system and contains a domain similar to Wiskott-Aldrich syndrome protein homology region 1 (WH1) in addition to the FK506-binding protein motif. FKBP15 is distributed along the axonal shafts and partially co-localizes with F-actin in the growth cones of dorsal root ganglion neurons; overexpression of FKBP15 resulted in the number of filopodia in transfected neurons, suggesting that FKBP15 modulates growth cone behavior. FKBP15 has also been shown to associate with both microtubules and the actin filament systems and disruption of its expression by RNAi resulted in delayed transport of early endosomes in HeLa cells indicating that FKBP15 is also involved in the transport of early endosomes. At least three isoforms of FKBP15 are known to exist.

Boster Bio Anti-FK506-binding protein 15 FKBP15 Antibody (Catalog # A10447) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

FKBP133, PPP1R76, KIAA0674, FK506-binding protein 15, 133 kDa FK506-binding protein, FKBP-15

FKBP15

Q5T1M5

Human, Mouse, Rat

FKBP15 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human FKBP15. The immunogen is located within amino acids 30 - 80 of FKBP15.

ELISA, WB, IHC-P, IF

Neuroscience

FKBP15 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

May be involved in the cytoskeletal organization of neuronal growth cones. Seems to be inactive as a PPIase (By similarity) . Involved in the transport of early endosomes at the level of transition between microfilament-based and microtubule- based movement.

FKBP15 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A10447

133630 MW

FK506 binding protein 15, 133kDa

Cytoplasm

FK506 binding protein 15, 133kDa

IgG

FKBP15 Antibody is supplied in PBS containing 0.02% sodium azide.