Anti-FKBP10 Antibody Picoband®

FK506-binding protein 10 is a protein that in humans is encoded by the FKBP10 gene. The protein encoded by this gene belongs to the FKBP-type peptidyl-prolyl cis/trans isomerase (PPIase) family. This protein localizes to the endoplasmic reticulum and acts as a molecular chaperone. Alternatively spliced variants encoding different isoforms have been reported, but their biological validity has not been determined.

Boster Bio Anti-FKBP10 Antibody Picoband® catalog # A05217-1. Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Histone deacetylase 10; HD10; HDAC10

FKBP10

60681

Q96AY3

Human

No cross-reactivity with other proteins.

E.coli-derived human FKBP10 recombinant protein (Position: R29-E532) .

Ubiquitous. High expression in liver, spleen, pancreas and kidney.

WB, ICC, IF, Flow Cytometry, ELISA

Acetylation, Chromatin Modifying Enzymes, Class I, Epigenetics and Nuclear Signaling, Signaling Pathways, Stem Cells

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.

1. Alanay, Y., Avaygan, H., Camacho, N., Utine, G. E., Boduroglu, K., Aktas, D., Alikasifoglu, M., Tuncbilek, E., Orhan, D., Bakar, F. T., Zabel, B., Superti-Furga, A., and 12 others. Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. Am. J. Hum. Genet. 86: 551-559, 2010. Note: Erratum: Am. J. Hum. Genet. 87: 572-573, 2010. 2. Alanay, Y., Krakow, D. Response to Shaheen et al. (Letter) Am. J. Hum. Genet. 87: 308 only, 2010. 3. Bank, R. A., Robins, S. P., Wijmenga, C., Breslau-Siderius, L. J., Bardoel, A. F. J., Van der Sluijs, H. A., Pruijs, H. E. H., TeKoppele, J. M. Defective collagen crosslinking in bone, but not in ligament or cartilage, in Bruck syndrome: indications for a bone-specific telopeptide lysyl hydroxylase on chromosome 17. Proc. Nat. Acad. Sci. 96: 1054-1058, 1999.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A05217-1

39411 MW

72 kDa

6

Histone deacetylase 10

Cytoplasm. Nucleus. Excluded from the nucleoli.

Long-chain-fatty-acid--CoA ligase 5

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.