Anti-FMO5 Antibody Picoband® 31.0550 Vervoeging

Dimethylaniline monooxygenase[N-oxide-forming] 5 also known as FMO 5 is an enzyme that in humans is encoded by the FMO5 gene. By fluorescence in situ hybridization, this gene was assigned to human chromosome 1q21.1. FMO5 is not an efficient drug-metabolizing enzyme and that it may have an alternative physiologic role. FMO5 transcripts play an important role in progesterone-regulated in breast cancer cells specifically under the control of the progesterone receptor B-isoform.

Dimethylaniline monooxygenase [N-oxide-forming] 5;1.14.13.8; Dimethylaniline oxidase 5; Hepatic flavin-containing monooxygenase 5; FMO 5; FMO5

FMO5

2330

P49326

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human FMO5, different from the related rat sequence by one amino acid, and different from the related mouse sequence by two amino acids.

Expressed in fetal and adult liver.

Flow Cytometry

Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

In contrast with other forms of FMO it does not seem to be a drug-metabolizing enzyme.

1. Gelb, B. D., Zhang, J., Cotter, P. D., Gershin, I. F., Desnick, R. J. Physical mapping of the human connexin 40 (GJA5), flavin-containing monooxygenase 5, and natriuretic peptide receptor A genes on 1q21. Genomics 39: 409-411, 1997. 2. Miller, M. M., James, R. A., Richer, J. K., Gordon, D. F., Wood, W. M., Horwitz, K. B.Progesterone regulated expression of flavin-containing monooxygenase 5 by the B-isoform of progesterone receptors: implications for tamoxifen carcinogenicity. J. Clin. Endocr. Metab. 82: 2956-2961, 1997. 3. Overby, L. H., Buckpitt, A. R., Lawton, M. P., Atta-Asafo-Adjei, E., Schulze, J., Philpot, R. M. Characterization of flavin-containing monooxygenase 5 (FMO5) cloned from human and guinea pig: evidence that the unique catalytic properties of FMO5 are not confined to the rabbit ortholog. Arch. Biochem. Biophys. 317: 275-284, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

60221 MW

No cross reactivity with other proteins.

6

Dimethylaniline monooxygenase [N-oxide-forming] 5

Microsome membrane. Endoplasmic reticulum membrane.

Belongs to the FMO family.

Dimethylaniline monooxygenase[N-oxide-forming] 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.