Anti-Fractalkine CX3CL1 Antibody Picoband® fluoro488 Vervoeging

Chemokine (C-X3-C motif) ligand 1, also known as CX3CL1, is a large cytokine protein. It is said to be the only known member of the CX3C chemokine family. It is also commonly known under the names fractalkine (in humans) and neurotactin (in mice) . Its gene is mapped to the long arm of chromosome 8. Being the large protein, it has got 373 amino acids. Imai et al. (1997) identified a 7-transmembrane high-affinity receptor (CX3CR1; 601470) for fractalkine and showed that it mediates both the adhesive and migratory functions of fractalkine.

Fractalkine; C-X3-C motif chemokine 1; CX3C membrane-anchored chemokine; Neurotactin; Small-inducible cytokine D1; Processed fractalkine; Cx3cl1; Cx3c, Fkn, Scyd1

CX3CL1

20312

O35188

Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of mouse CX3CL1, identical to the related rat sequence.

Highest levels in brain. Lower levels in kidney, heart and lung. Also found in skeletal muscle and testis.

Flow Cytometry

Atherosclerosis, Cardiovascular, Chemokines, Immunology, Innate Immunity, Macrophage/Inflammation, Vascular Inflammation

Immunogen affinity purified.

Liquid

The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. May play a role in regulating leukocyte adhesion and migration processes at the endothelium (By similarity) . Binds to CX3CR1. .

1. Pan et al., Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo JA, Vath J, Gosselin M et al. (1997) . Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387 (6633) : 611–617. doi:10.1038/42491. PMID 9177350. 2. Bazan et al., Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A et al. (1997) . A new class of membrane-bound chemokine with a CX3C motif. Nature 385 (6617) : 640–644. doi:10.1038/385640a0. PMID 9024663. 3. Hannan, N. J., Jones, R. L., Critchley, H. O. D., Kovacs, G. J., Rogers, P. A. W., Affandi, B., Salamonsen, L. A.Coexpression of fractalkine and its receptor in normal human endometrium and in endometrium from users of progestin-only contraception supports a role of fractalkine in leukocyte recruitment and endometrial remodeling.J. Clin. Endocr. Metab.89: 6119-6129, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

42099 MW

No cross reactivity with other proteins.

6

Fractalkine

Cell membrane; Single-pass type I membrane protein.

Fractalkine

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.