Anti-FRK Antibody Picoband® fluoro550 Vervoeging

Fyn-related kinase (Frk) is a tyrosine kinase of the Src family. Also known as Rak, Gtk, and Iyk, Frk is predominantly expressed in epithelial tissues. Frk protein is 49% and 47% identical to Fyn and Csk, respectively. Src family kinases regulate an array of cellular processes, including growth factor signaling, cytoskeleton dynamics, and cell proliferation.

Carbonic anhydrase 12; Carbonate dehydratase XII; Carbonic anhydrase XII; CA-XII; Tumor antigen HOM-RCC-3.1.3; CA12

FRK

2444

P42685

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human FRK recombinant protein (Position: Q39-A339) .

Highly expressed in colon, kidney, prostate, intestine and activated lymphocytes. Expressed at much higher levels in the renal cell cancers than in surrounding normal kidney tissue. Moderately expressed in pancreas, ovary and testis. Expressed in sweat glands and bronchiolar epithelium (PubMed:26911677) .

Flow Cytometry

Cancer, Cardiovascular, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction

Immunogen affinity purified.

Liquid

Reversible hydration of carbon dioxide.

1. Anneren, C., Reedquist, K. A., Bos, J. L., Welsh, M. GTK, a Src-related tyrosine kinase, induces nerve growth factor-independent neurite outgrowth in PC12 cells through activation of the Rap1 pathway: relationship to Shb tyrosine phosphorylation and elevated levels of focal adhesion kinase. J. Biol. Chem. 275: 29153-29161, 2000. 2. Cance, W. G., Craven, R. J., Bergman, M., Xu, L., Alitalo, K., Liu, E. T. Rak, a novel nuclear tyrosine kinase expressed in epithelial cells. Cell Growth Differ. 5: 1347-1355, 1994. 3. Cance, W. G., Craven, R. J., Weiner, T. M., Liu, E. T. Novel protein kinases expressed in human breast cancer. Int. J. Cancer 54: 571-

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

17184 MW

6

Carbonic anhydrase 12

Cell membrane; Membrane; Single-pass type I membrane protein

Acid-sensing ion channel 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.