Anti-FXI/F11 Antibody Picoband® fluoro647 Vervoeging

Factor XI or plasma thromboplastin antecedent is the zymogen form of factor XIa, one of the enzymes of the coagulation cascade. Like many other coagulation factors, it is a serine protease. In humans, Factor XI is encoded by the F11 gene. This gene encodes coagulation factor XI of the blood coagulation cascade. This protein is present in plasma as a zymogen, which is a unique plasma coagulation enzyme because it exists as a homodimer consisting of two identical polypeptide chains linked by disulfide bonds. During activation of the plasma factor XI, an internal peptide bond is cleaved by factor XIIa (or XII) in each of the two chains, resulting in activated factor XIa, a serine protease composed of two heavy and two light chains held together by disulfide bonds. This activated plasma factor XI triggers the middle phase of the intrisic pathway of blood coagulation by activating factor IX. Defects in this factor lead to Rosenthal syndrome, a blood coagulation abnormality.

Purine nucleoside phosphorylase; PNP;2.4.2.1; Inosine phosphorylase; Inosine-guanosine phosphorylase; PNP; NP

F11

2160

P03951

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human FXI/F11 recombinant protein (Position: K79-Q155) .

Expressed in red blood cells; overexpressed in red blood cells (cytoplasm) of patients with hereditary non- spherocytic hemolytic anemia of unknown etiology. .

Flow Cytometry

Cofactors, Vitamins/Minerals, Metabolism, Neuroscience, Neurotransmitter, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Immunogen affinity purified.

Liquid

The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy) ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. .

1. Asakai, R., Chung, D. W., Davie, E. W., Seligsohn, U. Factor XI deficiency in Ashkenazi Jews in Israel. New Eng. J. Med. 325: 153-158, 1991. 2. Asakai, R., Chung, D. W., Ratnoff, O. D., Davie, E. W. Factor XI (plasma thromboplastin antecedent) deficiency in Ashkenazi Jews is a bleeding disorder that can result from three types of point mutations. Proc. Nat. Acad. Sci. 86: 7667-7671, 1989. 3. Asakai, R., Davie, E. W., Chung, D. W. Organization of the gene for human factor XI. Biochemistry 26: 7221-7228, 1987.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

32118 MW

6

Purine nucleoside phosphorylase

Cytoplasm, cytoskeleton . Cytoplasm .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.