Anti-FXR1 Antibody Picoband® 310647 Vervoeging

Fragile X mental retardation syndrome-related protein 1 is a protein that in humans is encoded by the FXR1 gene. The protein encoded by this gene is an RNA binding protein that interacts with the functionally-similar proteins FMR1 and FXR2. These proteins shuttle between the nucleus and cytoplasm and associate with polyribosomes, predominantly with the 60S ribosomal subunit. Three transcript variants encoding different isoforms have been found for this gene.

Glutathione S-transferase Mu 3; GST class-mu 3; GSTM3-3; hGSTM3-3; GSTM3; GST5

FXR1

8087

P51114

Human, Mouse, Rat, Monkey

No cross-reactivity with other proteins.

E.coli-derived human FXR1 recombinant protein (Position: D149-A614) .

Testis and brain.

Flow Cytometry

Cancer, Drug Metabolism, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May govern uptake and detoxification of both endogenous compounds and xenobiotics at the testis and brain blood barriers.

1. Bolivar, J., Guelman, S., Iglesias, C., Ortiz, M., Valdivia, M. M. The fragile-X-related gene FXR1 is a human autoantigen processed during apoptosis. J. Biol. Chem. 273: 17122-17127, 1998. 2. Coy, J. F., Sedlacek, Z., Bachner, D., Hameister, H., Joos, S., Lichter, P., Delius, H., Poustka, A. Highly conserved 3-prime UTR and expression pattern of FXR1 points to a divergent gene regulation of FXR1 and FMR1. Hum. Molec. Genet. 4: 2209-2218, 1995. 3. Darnell, J. C., Fraser, C. E., Mostovetsky, O., Darnell, R. B. Discrimination of common and unique RNA-binding activities among fragile X mental retardation protein paralogs. Hum. Molec. Genet. 18: 3164-3177, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Glutathione S-transferase mu 3

Cytoplasm.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.