Anti-GALC Antibody Picoband® fluoro550 Vervoeging

This gene encodes a lysosomal protein which hydrolyzes the galactose ester bonds of galactosylceramide, galactosylsphingosine, lactosylceramide, and monogalactosyldiglyceride. Mutations in this gene have been associated with Krabbe disease, also known as globoid cell leukodystrophy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

GALC; Galactocerebrosidase; GALCERase; EC 3.2.1.46; Galactocerebroside beta-galactosidase; Galactosylceramidase; Galactosylceramide beta-galactosidase

GALC

2581

P54803

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human GALC.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Cannizzaro, L. A., Chen, Y. Q., Rafi, M. A., Wenger, D. A. Regional mapping of the human galactocerebrosidase gene (GALC) to 14q31 by in situ hybridization. Cytogenet. Cell Genet. 66: 244-245, 1994. 2. Chen, Y. Q., Rafi, M. A., de Gala, G., Wenger, D. A. Cloning and expression of cDNA encoding human galactocerebrosidase, the enzyme deficient in globoid cell leukodystrophy. Hum. Molec. Genet. 2: 1841-1845, 1993. 3. Chen, Y. Q., Wenger, D. A. Galactocerebrosidase from human urine: purification and partial characterization. Biochim. Biophys. Acta 1170: 53-61, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

77 kDa

6

Galactosylceramidase

Galactocerebrosidase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.