Anti-GALNT7 Antibody Picoband® fluoro488 Vervoeging

This gene encodes GalNAc transferase 7, a member of the GalNAc-transferase family. The enzyme encoded by this gene controls the initiation step of mucin-type O-linked protein glycosylation and transfer of N-acetylgalactosamine to serine and threonine amino acid residues. This enzyme is a type II transmembrane protein and shares common sequence motifs with other family members. Unlike other family members, this enzyme shows exclusive specificity for partially GalNAc-glycosylated acceptor substrates and shows no activity with non-glycosylated peptides. This protein may function as a follow-up enzyme in the initiation step of O-glycosylation.

GALNT7

51809

Q86SF2

Human, Mouse, Rat

E.coli-derived human GALNT7 recombinant protein (Position: K67-V657) . Human GALNT7 shares 95.6% and 95.8% amino acid (aa) sequence identity with mouse and rat GALNT7, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Bennett, E. P., Hassan, H., Hollingsworth, M. A., Clausen, H. A novel human UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, GalNAc-T7, with specificity for partial GalNAc-glycosylated acceptor substrates. FEBS Lett. 460: 226-230, 1999. 2. Gaziel-Sovran, A., Segura, M. F., Di Micco, R., Collins, M. K., Hanniford, D., Vega-Saenz de Miera, E., Rakus, J. F., Dankert, J. F., Shang, S., Kerbel, R. S., Bhardwaj, N., Shao, Y., Darvishian, F., Zavadil, J., Erlebacher, A., Mahal, L. K., Osman, I., Hernando, E. miR-30b/30d regulation of GalNAc transferases enhances invasion and immunosuppression during metastasis. Cancer Cell 20: 104-118, 2011. 3. Peng, C., Togayachi, A., Kwon, Y.-D., Xie, C., Wu, G., Zou, X., Sato, T., Ito, H., Tachibana, K., Kubota, T., Noce, T., Narimatsu, H., Zhang, Y. Identification of a novel human UDP-GalNAc transferase with unique catalytic activity and expression profile. Biochem. Biophys. Res. Commun. 402: 680-686, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.