Anti-gamma Synucleïne/SNCG Antibody Picoband® fluoro488 Vervoeging

Gamma-synuclein is a protein that in humans is encoded by the SNCG gene. This gene encodes a member of the synuclein family of proteins which are believed to be involved in the pathogenesis of neurodegenerative diseases. Mutations in this gene have also been associated with breast tumor development.

Laminin subunit gamma-1; Laminin B2 chain; Laminin-1 subunit gamma; Laminin-10 subunit gamma; Laminin-11 subunit gamma; Laminin-2 subunit gamma; Laminin-3 subunit gamma; Laminin-4 subunit gamma; Laminin-6 subunit gamma; Laminin-7 subunit gamma; Laminin-8 subunit gamma; Laminin-9 subunit gamma; S-laminin subunit gamma; S-LAM gamma; Lamc1; Lamb-2, Lamc-1

SNCG

6623

O76070

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human gamma Synuclein/SNCG, which shares 53.8% amino acid (aa) sequence identity with rat SNCG.

Found in the basement membranes (major component) .

Flow Cytometry

Cytoskeleton/ECM, Extracellular Matrix, Signal Transduction

Immunogen affinity purified.

Liquid

Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

1. Ji, H., Liu, Y. E., Jia, T., Wang, M., Liu, J., Xiao, G., Joseph, B. K., Rosen, C., Shi, Y. E. Identification of a breast cancer-specific gene, BCSG1, by differential cDNA sequencing. Cancer Res. 57: 759-764, 1997. 2. Lavedan, C., Buchholtz, S., Auburger, G., Albin, R. L., Athanassiadou, A., Blancato, J., Burguera, J. A., Ferrell, R. E., Kostic, V., Leroy, E., Leube, B., Mota-Vieira, L., and 9 others. Absence of mutation in the beta- and gamma-synuclein genes in familial autosomal dominant Parkinson's disease. DNA Res. 5: 401-402, 1998. 3. Lavedan, C., Leroy, E., Dehejia, A., Buchholtz, S., Dutra, A., Nussbaum, R. L., Polymeropoulos, M. H. Identification, localization and characterization of the human gamma-synuclein gene. Hum. Genet. 103: 106-112, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

177298 MW

6

Laminin subunit gamma-1

Secreted, extracellular space, extracellular matrix, basement membrane.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.