Anti-Gankyrine/PSMD10 Antibody Picoband® APC-vervoeging

This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.

PSMD10; 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; Gankyrin; p28 (GANK

PSMD10

5716

O75832

Human

No cross-reactivity with other proteins

E.coli-derived human Gankyrin/PSMD10 recombinant protein (Position: M1-G226) . Human Gankyrin/PSMD10 shares 94.2% and 94.7% amino acid (aa) sequence identity with mouse and rat Gankyrin/PSMD10, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Dong, L., Yang, G., Pan, Y., Chen, Y., Tan, Y., Dai, R., Ren, Y., Fu, J., Wang, H. The oncoprotein p28 (GANK) establishes a positive feedback loop in beta-catenin signaling. Cell Res. 21: 1248-1261, 2011. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 9/26/2012. 3. Hori, T., Kato, S., Saeki, M., DeMartino, G. N., Slaughter, C. A., Takeuchi, J., Toh-e, A., Tanaka, K. cDNA cloning and functional analysis of p28 (Nas6p) and p40.5 (Nas7p), two novel regulatory subunits of the 26S proteasome. Gene 216: 113-122, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24 kDa

6

Proteasome 26S subunit, non-ATPase 10

26S proteasome non-ATPase regulatory subunit 10

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.