Anti-Gap junction beta-2 proteïne GJB2 Antibody Picoband® fluoro594 Vervoeging

Connexin26 (CX26), also known as GAP junction protein, beta2, GJB2. Gap junctions were first characterized by electron microscopy as regionally specialized structures on plasma membranes of contacting adherent cells. These structures were shown to consist of cell-to-cell channels. Proteins, called connexins, purified from fractions of enriched gap junctions from different tissues differ. The 3-prime untranslated region of the CX26 transcript contains a putative mRNA instability sequence. The deduced 226-amino acid protein has a calculated molecular mass of about 26 kD. CX26 shares 92.5% identity with rat Cx26. connexin 26 (GJB2) is assigned to human chromosome 13q11-q12 .Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation.

Gap junction beta-2 protein; Connexin-26; Cx26; GJB2

GJB2

2706

P29033

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human GJB2, different from the related mouse and rat sequences by one amino acid.

Isoform 10 (epithelial isoform) is expressed by cells of epithelium and highly expressed by carcinomas. Expression is repressed in neuroblastoma cells.

Flow Cytometry

Auditory System, Cell Adhesion, Cytoskeleton/ECM, Neuroscience, Sensory System, Signal Transduction

Immunogen affinity purified.

Liquid

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

1. Mignon, C.; Fromaget, C.; Mattei, M.-G.; Gros, D.; Yamasaki, H.; Mesnil, M. : Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human chromosome 13q11-q12 and mouse chromosome 14D1-E1 by in situ hybridization. Cytogenet. Cell Genet. 72: 185-186, 1996. 2. Djalilian, A. R.; McGaughey, D.; Patel, S.; Seo, E. Y.; Yang, C.; Cheng, J.; Tomic, M.; Sinha, S.; Ishida-Yamamoto, A.; Segre, J. A. : Connexin 26 regulates epidermal barrier and wound remodeling and promotes psoriasiform response. J. Clin. Invest. 116: 1243-1253, 2006. 3. Abe, S.; Kelley, P. M.; Kimberling, W. J.; Usami, S. : Connexin 26 gene (GJB2) mutation modulates the severity of hearing loss associated with the 1555A-G mitochondrial mutation. Am. J. Med. Genet. 103: 334-338, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26215 MW

No cross reactivity with other proteins.

6

Gap junction beta-2 protein

Cell membrane; Multi-pass membrane protein. Cell junction, gap junction.

Belongs to the connexin family. Beta-type (group I) subfamily.

Gap junction beta-2 protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.