Anti-GATA1 Antibody Picoband® fluoro488 Vervoeging

GATA-binding factor 1 or GATA-1 (also termed Erythroid transcription factor) is the founding member of the GATA family of transcription factors. The protein plays an important role in erythroid development by regulating the switch of fetal hemoglobin to adult hemoglobin. Mutations in this gene have been associated with X-linked dyserythropoietic anemia and thrombocytopenia.

Serine/threonine-protein kinase MAK;2.7.11.22; Male germ cell-associated kinase; MAK

GATA1

2623

P15976

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human GATA1 recombinant protein (Position: A58-R317) .

Expressed in prostate cancer cell lines at generally higher levels than in normal prostate epithelial cell lines. Isoform 1 is expressed in kidney, testis, lung, trachea, and retina. Isoform 2 is retina-specific where it is expressed in rod and cone photoreceptors. .

Flow Cytometry

Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction

Immunogen affinity purified.

Liquid

Essential for the regulation of ciliary length and required for the long-term survival of photoreceptors (By similarity) . Phosphorylates FZR1 in a cell cycle-dependent manner. Plays a role in the transcriptional coactivation of AR. Could play an important function in spermatogenesis. May play a role in chromosomal stability in prostate cancer cells. .

1. Ahmed, M., Sternberg, A., Hall, G., Thomas, A., Smith, O., O'Marcaigh, A., Wynn, R., Stevens, R., Addison, M., King, D., Stewart, B., Gibson, B., Roberts, I., Vyas, P. Natural history of GATA1 mutations in Down syndrome. Blood 103: 2480-2489, 2004. 2. Balduini, C. L., De Candia, E., Savoia, A. Why the disorder induced by GATA1 arg216gln mutation should be called 'X-linked thrombocytopenia with thalassemia' rather than 'X-linked gray platelet syndrome'. (Letter) Blood 110: 2770-2771, 2007. 3. Blobel, G. A., Nakajima, T., Eckner, R., Montminy, M., Orkin, S. H. CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation. Proc. Nat. Acad. Sci. 95: 2061-2066, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

70581 MW

6

Serine/threonine-protein kinase MAK

Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell projection, cilium, photoreceptor outer segment . Photoreceptor inner segment. Localized in both the connecting cilia and the outer segment axonemes (By similarity) . Localized uniformly in nuclei during interphase, to the mitotic spindle and centrosomes during metaphase and anaphase, and also to midbody at anaphase until telophase. .

Keratin, type II cytoskeletal 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.