Anti-GATA2 Antibody Picoband® 0,00647 Vervoeging

GATA2 (GATA binding protein 2) is a human gene which makes a protein called GATA binding protein 2 - a transcription factor. The GATA family of transcription factors, which contain zinc fingers in their DNA binding domain, have emerged as candidate regulators of gene expression in hematopoietic cells. Ciciotte et al. (1997) mapped the mouse Gata2 gene to chromosome 6 by study of DNA from an interspecific backcross panel. They pointed out that the human gene had been mapped to chromosome 3 by Dorfman et al. (1992) using DNA from a panel of 12 rodent/human hybrids containing various human chromosomes and applying Southern blot analysis. By exon trapping using a PAC contig spanning a breakpoint region associated with myeloid leukemia, Wieser et al. (2000) mapped the GATA2 gene to chromosome 3q21. GATA2 is transcribed from telomere to centromere. GATA2 is expressed in hematopoietic progenitors, including early erythroid cells, mast cells, and megakaryocytes, and also in nonhematopoietic embryonic stem cells.

Endothelial transcription factor GATA-2; GATA-binding protein 2; GATA2

GATA2

2624

P23769

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human GATA2, identical to the related rat and mouse sequences.

Endothelial cells.

Flow Cytometry

Cardiogenesis, Cardiovascular,2339, Developmental Biology, Domain Families, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Stem Cells, Transcription, Transcription Factors/Regulators, Zinc Finger

Immunogen affinity purified.

Liquid

Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5'-AGATAG-3'.

1. Ciciotte, S. L., Tsai, F.-Y., Peters, L. L.Gata2 maps to mouse chromosome 6.Mammalian Genome 8: 69-70, 1997. 2. Dorfman, D. M., Wilson, D. B., Bruns, G. A., Orkin, S. H.Human transcription factor GATA-2: evidence for regulation of preproendothelin-1 gene expression in endothelial cells.J. Biol. Chem. 267: 1279-1285, 1992. 3. Wieser, R., Volz, A., Vinatzer, U., Gardiner, K., Jager, U., Mitterbauer, M., Ziegler, A., Fonatsch, C.Transcription factor GATA-2 gene is located near 3q21 breakpoints in myeloid leukemia.Biochem. Biophys. Res. Commun. 273: 239-245, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

50500 MW

No cross reactivity with other proteins.

6

Endothelial transcription factor GATA-2

Nucleus.

Contains 2 GATA-type zinc fingers.

Endothelial transcription factor GATA-2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.