Anti-GCM1 Antibody Picoband® 31.0550 Vervoeging

Chorion-specific transcription factor GCMa is a protein that, in humans, is encoded by the GCM1 gene. This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif) . The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm) . This protein binds to the GCM-motif (A/G) CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein.

Vascular endothelial growth factor B; VEGF-B; VEGF-related factor; VRF; VEGFB; VRF

GCM1

8521

Q9NP62

Human

No cross-reactivity with other proteins.

E.coli-derived human GCM1 recombinant protein (Position: E188-R436) .

Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Neurogenesis, Neurology Process, Neuroscience, Signal Transduction

Immunogen affinity purified.

Liquid

Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.

1. Akiyama, Y., Hosoya, T., Poole, A. M., Hotta, Y. The gcm-motif: a novel DNA-binding motif conserved in Drosophila and mammals. Proc. Nat. Acad. Sci. 93: 14912-14916, 1996. 2. Anson-Cartwright, L., Dawson, K., Holmyard, D., Fisher, S. J., Lazzarini, R. A., Cross, J. C. The glial cells missing-1 protein is essential for branching morphogenesis in the chorioallantoic placenta. Nature Genet. 25: 311-314, 2000. 3. Gunther, T., Chen, Z.-F., Kim, J., Priemel, M., Rueger, J. M., Amling, M., Moseley, J. M., Martin, T. J., Anderson, D. J., Karsenty, G. Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. Nature 406: 199-203, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Vascular endothelial growth factor B

Secreted. Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.