Anti-GCSF Receptor/CSF3R Antibody Picoband® fluoro550 Vervoeging

CSF3R (Colony-Stimulating Factor 3 Receptor, Granulocyte) also known as GCSFR or CD114 ((Cluster of Differentiation 114) is a protein that in humans is encoded by the CSF3R gene. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF) . The G-CSF receptors belongs to a family of cytokine receptors known as the hematopoietin receptor family. The CSF3R gene consists of 17 exons. By in situ hybridization using human CSF3R cDNA as a probe, Inazawa et al. (1991) localized the gene to 1p35-p34.3. The G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, and Erk1/2. Dong et al. (2001) reported that the C terminus of CSF3R is required for SHP1 downregulation of CSF3-induced STAT activation. The authors proposed that this mechanism inhibits cell proliferation and survival in response to CSF3.

Granulocyte colony-stimulating factor receptor; G-CSF receptor; G-CSF-R; CD114; CSF3R; GCSFR

CSF3R

1441

Q99062

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human GCSF Receptor.

One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.

Flow Cytometry

Cancer, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Oncoproteins, Oncoproteins/Suppressors, Stem Cells, Surface Molecules

Immunogen affinity purified.

Liquid

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface. .

1. Dong, F., Qiu, Y., Yi, T., Touw, I. P., Larner, A. C. The carboxyl terminus of the granulocyte colony-stimulating factor receptor, truncated in patients with severe congenital neutropenia/acute myeloid leukemia, is required for SH2-containing phosphatase-1 suppression of Stat activation. J. Immun. 167: 6447-6452, 2001. 2. Inazawa, J., Fukunaga, R., Seto, Y., Nakagawa, H., Misawa, S., Abe, T., Nagata, S. Assignment of the human granulocyte colony-stimulating factor receptor gene (CSF3R) to chromosome 1 at region p35-p34.3. Genomics 10: 1075-1078, 1991. 3. Plo, I., Zhang, Y., Le Couedic, J.-P., Nakatake, M., Boulet, J.-M., Itaya, M., Smith, S. O., Debili, N., Constantinescu, S. N., Vainchenker, W., Louache, F., de Botton, S. An activating mutation in the CSF3R gene induces a hereditary chronic neutrophilia. J. Exp. Med. 206: 1701-1707, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

92156 MW

No cross reactivity with other proteins.

6

Granulocyte colony-stimulating factor receptor

Isoform 2: Secreted .

Belongs to the type I cytokine receptor family. Type 2 subfamily.

Granulocyte colony-stimulating factor receptor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.