Anti-GDNF Antibody Picoband® fluoro488 Vervoeging

GDNF, Glial cell-derived neurotrophic factor, is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. GDNF is a founding member of the GDNF family of ligands (GFL) . The GDNF gene is mapped to human chromosome 5p13.1-p12 by fluorescence in situ hybridization (FISH) . This gene encodes a highly conserved neurotrophic factor. The recombinant form of this protein was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosisof motor neurons induced by axotomy. The encoded protein is processed to a mature secreted form that exists as a homodimer. The mature form of the protein is a ligand for the product of the RET (rearranged during transfection) protooncogene.

Glial cell line-derived neurotrophic factor; hGDNF; Astrocyte-derived trophic factor; ATF; GDNF

GDNF

2668

P39905

Human, Rat

No cross-reactivity with other proteins

Human GDNF

In the brain, predominantly expressed in the striatum with highest levels in the caudate and lowest in the putamen. Isoform 2 is absent from most tissues except for low levels in intestine and kidney. Highest expression of isoform 3 is found in pancreatic islets. Isoform 5 is expressed at very low levels in putamen, nucleus accumbens, prefrontal cortex, amygdala, hypothalamus and intestine. Isoform 3 is up-regulated in the middle temporal gyrus of Alzheimer disease patients while isoform 2 shows no change. .

Flow Cytometry

Developmental Biology, Growth and Development, Neurodegenerative Disease, Neurology Process, Neuroscience, Organogenesis

Immunogen affinity purified.

Liquid

Neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake. .

1. Iwashita, T., Kruger, G. M., Pardal, R., Kiel, M. J., Morrison, S. J.Hirschsprung disease is linked to defects in neural crest stem cell function.Science 301: 972-976, 2003. 2. Lin, L.-F. H., Doherty, D. H., Lile, J. D., Bektesh, S., Collins, F.GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons.Science 260: 1130-1132, 1993. 3. Schindelhauer, D., Schuffenhauer, S., Gasser, T., Steinkasserer, A., Meitinger, T.The gene coding for glial cell line derived neurotrophic factor (GDNF) maps to chromosome 5p12-p13.1.Genomics 28: 605-607, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

23720 MW

No cross reactivity with other proteins.

6

Glial cell line-derived neurotrophic factor

Secreted .

Belongs to the TGF-beta family. GDNF subfamily.

Glial cell line-derived neurotrophic factor (hGDNF)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.