Anti-GFAP Antibody Picoband® fluoro594 Vervoeging

Glial fibrillary acidic protein (GFAP) is an intermediate-filament (IF) protein that is highly specific for cells of astroglial lineage, although its tissue-specific role is speculative. GFAP has been located in rat kidney glomeruli and peritubular fibroblasts, leydig cells of testis, skin keratinocytes, osteocytes of bones, chondrocytes of epiglottis, bronchus, and stellate-shaped cells of the pancreas and liver. Its expression is essential for normal white matter architecture and blood-brain barrier integrity, and its absence leads to late-onset CNS dysmyelination. GFAP has also been shown to play a role in mitosis by adjusting the filament network present in the cell. During mitosis, there is an increase in the amount of phosphorylated GFAP, and a movement of this modified protein to the cleavage furrow.

Glial fibrillary acidic protein; GFAP; GFAP

GFAP

2670

P14136

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human GFAP, identical to the related rat sequence, and different from the related mouse sequence by two amino acids.

Expressed in cells lacking fibronectin. .

Flow Cytometry

Cell Adhesion Proteins, Cell Type Marker, Cell Type Markers, Cytoskeleton, Cytoskeleton/ECM, Intermediate Filaments, Neural Stem Cells, Neuroscience, Signal Transduction, Stem Cells, Tags & Cell Markers

Immunogen affinity purified.

Liquid

GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

1. Reeves SA, Helman LJ, Allison A, Israel MA (1989) . Molecular cloning and primary structure of human glial fibrillary acidic protein. Proc. Natl. Acad. Sci. U.S.A. 86 (13) : 5178–82. 2. Liedtke W, Edelmann W, Bieri PL, Chiu FC, Cowan NJ, Kucherlapati R, Raine CS (1996) . GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. Neuron 17 (4) : 607–15. 3. Tardy M, Fages C, Le Prince G, Rolland B, Nunez J (1990) . Regulation of the glial fibrillary acidic protein (GFAP) and of its encoding mRNA in the developing brain and in cultured astrocytes. Adv. Exp. Med. Biol. 265: 41–52.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49880 MW

No cross reactivity with other proteins.

6

Glial fibrillary acidic protein

Cytoplasm . Associated with intermediate filaments.

Belongs to the intermediate filament family.

Glial fibrillary acidic protein (GFAP)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.