Anti-GFAP Antibody Picoband® fluoro594 Vervoeging

Glial fibrillary acidic protein (GFAP) is a protein that is encoded by the GFAP gene in humans. It is an intermediate filament (IF) protein that is expressed by numerous cell types of the central nervous system (CNS) including astrocytes, and ependymal cells. It is mapped to 17q21.31. GFAP is closely related to its non-epithelial family members, vimentin, desmin, and peripherin, which are all involved in the structure and function of the cell’ s cytoskeleton. GFAP is thought to help to maintain astrocyte mechanical strength, as well as the shape of cells. This gene has been shown to play a role in mitosis by adjusting the filament network present in the cell. GFAP is necessary for many critical roles in the CNS. What’ s more, GFAP also plays a role in astrocyte-neuron interactions as well as cell-cell communication.

Glial fibrillary acidic protein; GFAP; GFAP

GFAP

2670

P14136

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human GFAP recombinant protein (Position: Q93-M432) . Human GFAP shares 94% amino acid (aa) sequence identity with both mouse and rat GFAP.

Expressed in cells lacking fibronectin. .

Flow Cytometry

Cell Adhesion Proteins, Cell Type Marker, Cell Type Markers, Cytoskeleton, Cytoskeleton/ECM, Intermediate Filaments, Neural Stem Cells, Neuroscience, Signal Transduction, Stem Cells, Tags & Cell Markers

Immunogen affinity purified.

Liquid

GFAP, a class-III intermediate filament, is a cell- specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.

1. Eng LF, Ghirnikar RS, Lee YL (October 2000) . Glial fibrillary acidic protein: GFAP-thirty-one years (1969-2000) . Neurochem. Res. 25 (9-10) : 1439–51. 2. Tardy M, Fages C, Le Prince G, Rolland B, Nunez J (1990) . Regulation of the glial fibrillary acidic protein (GFAP) and of its encoding mRNA in the developing brain and in cultured astrocytes. Adv. Exp. Med. Biol. 265: 41–52. 3. Weinstein DE, Shelanski ML, Liem RK (1991) . Suppression by antisense mRNA demonstrates a requirement for the glial fibrillary acidic protein in the formation of stable astrocytic processes in response to neurons. The Journal of Cell Biology 112 (6) : 1205–1213.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49880 MW

No cross reactivity with other proteins.

6

Glial fibrillary acidic protein

Cytoplasm . Associated with intermediate filaments.

Belongs to the intermediate filament family.

Glial fibrillary acidic protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.