Anti-Girdin (C-terminus) Antilichaam

Girdin, a member of the CCDC88 (Hook related protein) family, is an actin binding protein involved with cell migration and maintaining cytoskeletal organization. Girdin has conserved domains at the N- and C-terminus that bind microtubules and actin, respectively. It enhances PI3-kinase dependent phosphorylation of proteins, most notably Akt. This same activity can contribute to tumor proliferation, invasion, and metastasis in breast, ovarian, prostate, and pancreatic tissues. Girdin is phosphorylated at three separate locations: Ser-1416, Ser-1674, and Tyr-1764. Ser-1416 is the primary Akt phosphorylation site, while Cyclin-dependent kinases interact with Girdin and phosphorylate Ser-1674. Multiple receptor tyrosine kinases can bind girdin and phosphorylate Tyr-1764.

Our Girdin (C-terminus) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human Girdin (C-terminus) and is protein g purified. It is great for use in ELISA, WB, ICC, IHC, IP.

Our Girdin (C-terminus) primary antibody from PhosphoSolutions is mouse monoclonal. It detects human Girdin (C-terminus) and is Protein G purified. It is great for use in WB, ICC, IHC, IP.

APE, Galpha, vesicle, GIV, Girders actin filament, HkRP1, GRDN, CCDC88A

CCDC88A

Q3V6T2

Human

Clone (M012) was generated from a recombinant protein that included amino acid residues within the C-terminal region of human Girdin.

Girdin (C-terminus)

M012

Unconjugated

ELISA, WB, ICC, IHC, IP

Cell Adhesion Molecules, Cell Signaling, Cytoskeletal Regulation, Neurogenesis and Development, Oncoproteins

Protein G Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

250

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Protein G purified culture supernatant.

1:50

1:250

1:50

Clone M012 mouse monoclonal antibody detects a 250 kDa* protein on SDS-PAGE immunoblots of human A431 cells and human brain tissue. The antibody also works for immmunoprecipitation, immunohistochemistry, and immunocytochemistry.

1:50

Western blots performed on each lot.

Mouse

Liquid

IgG1

Human

Quality Control: WB

AB_3068446