Anti-GITR / Tnfrsf18 (Mouse) Monoklonale Antilichaam (Kloon: DTA-1)

GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-alphaeceptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25+CD4+Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to aμgment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25+CD4+Tregs. In vivoactivation of GITR causes development of autoimmune diseases and restores the suppressed immune response.

Activation-inducible TNF-alphaelated ligand; AITRL; GITRL; Glucocorticoid induced TNFR related protein ligand; Glucocorticoid-induced TNF-alphaelated ligand; hGITRL; TL6; TNFSF18; Tumor necrosis factor (ligand) superfamily member 18

21936

O35714

Mouse

Mouse CD25+ CD4+ T cells

DTA-1

FACS, IF

200 μg/mL of Ab Purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/mL.

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous.

Flow Cytometry (0.5-1ug/million cells in 0.1ml) ; Immunofluorescence (1-2ug/ml)

Rat IgG2b, lambda