Anti-Glucose Transporter 5 GLUT5/SLC2A5 Antibody Picoband® 3100550 Vervoeging

SLC2A5, also known as GLUT5 (Glucose transporter 5), is a fructose transporter expressed on the apical border of enterocytes in the small intestine. The GLUT5 gene is located on chromosome 1. GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle, testis, kidney, fat tissue, and brain. Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient. In humans the GLUT5 protein is encoded by the SLC2A5 gene.

Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5; SLC2A5; GLUT5

SLC2A5

6518

P22732

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC2A5.

Expressed in small intestine, and at much lower levels in kidney, skeletal muscle, and adipose tissue.

Flow Cytometry

Cancer, Cancer Metabolism, Carbohydrate Metabolism, Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Pathways and Processes, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Cytochalasin B-sensitive carrier. Seems to function primarily as a fructose transporter.

1. Burant, C. F., Takeda, J., Brot-Laroche, E., Bell, G. I., Davidson, N. O.Fructose transporter in human spermatozoa and small intestine is GLUT5.J. Biol. Chem. 267: 14523-14526, 1992. 2. Davidson, N. O., Hausman, A. M. L., Ifkovits, C. A., Buse, J. B., Gould, G. W., Burant, C. F., Bell, G. I.Human intestinal glucose transporter expression and localization of GLUT5.Am. J. Physiol. 262: C795-C800, 1992. 3. Kayano, T., Burant, C. F., Fukumoto, H., Gould, G. W., Fan, Y. S., Eddy, R. L., Byers, M. G., Shows, T. B., Seino, S., Bell, G. I.Human facilitative glucose transporters: isolation, functional characterization, and gene localization of cDNAs encoding an isoform (GLUT5) expressed in small intestine, kidney, muscle, and adipose tissue and an unusual glucose transporter pseudogene-like sequence (GLUT6) .J. Biol. Chem. 265: 13276-13282, 1990.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

54974 MW

No cross reactivity with other proteins.

6

Solute carrier family 2, facilitated glucose transporter member 5

Apical cell membrane ; Multi- pass membrane protein . Membrane; Multi-pass membrane protein. Localized on the apical membrane of the small intestine and the proximal tubule of the kidney. .

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Solute carrier family 2, facilitated glucose transporter member 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.