Anti-GLUL Antibody Picoband® fluoro488 Vervoeging

The protein encoded by this gene belongs to the glutamine synthetase family. It catalyzes the synthesis of glutamine from glutamate and ammonia in an ATP-dependent reaction. This protein plays a role in ammonia and glutamate detoxification, acid-base homeostasis, cell signaling, and cell proliferation. Glutamine is an abundant amino acid, and is important to the biosynthesis of several amino acids, pyrimidines, and purines. Mutations in this gene are associated with congenital glutamine deficiency, and overexpression of this gene was observed in some primary liver cancer samples. There are six pseudogenes of this gene found on chromosomes 2, 5, 9, 11, and 12. Alternative splicing results in multiple transcript variants.

ETS-related transcription factor Elf-1; E74-like factor 1; ELF1

GLUL

2752

P15104

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human GLUL recombinant protein (Position: N74-N373) .

In fetal tissues, it is highly expressed in heart, lung liver and kidney, and weakly expressed in brain. In adult, it is highly expressed in pancreas, spleen, thymus and peripheral blood leukocytes, expressed at moderate levels in heart, placenta, lung, liver, skeletal muscle, kidney, prostate, ovary, small intestine and colon, and weakly expressed in brain and testis.

Flow Cytometry

Domain Families, Epigenetics and Nuclear Signaling, Transcription

Immunogen affinity purified.

Liquid

Transcription factor that activates the LYN and BLK promoters. Appears to be required for the T-cell-receptor-mediated trans activation of HIV-2 gene expression. Binds specifically to two purine-rich motifs in the HIV-2 enhancer.

1. Clancy, K. P., Berger, R., Cox, M., Bleskan, J., Walton, K. A., Hart, I., Patterson, D. Localization of the L-glutamine synthetase gene to chromosome 1q23. Genomics 38: 418-420, 1996. 2. Eelen, G., Dubois, C., Cantelmo, A. R., Goveia, J., Bruning, U., DeRan, M., Jarugumilli, G., van Rijssel, J., Saladino, G., Comitani, F., Zecchin, A., Rocha, S., and 27 others. Role of glutamine synthetase in angiogenesis beyond glutamine synthesis. Nature 561: 63-69, 2018. 3. Gibbs, C. S., Campbell, K. E., Wilson, R. H. Sequence of a human glutamine synthetase cDNA. Nucleic Acids Res. 15: 6293 only, 1987.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

E74 like ETS transcription factor 1

Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.