Anti-GluN2A/NR2A Glutamate Receptor (N327/95) Recombinant Chicken Chimeric mAb

Glutamate receptor NMDA2A or GluN2A/NR2A glutamate receptor is a member of the glutamate-gated ion channel family. NR2A is a subunit of the ligand-gated ion channel with high calcium permeability and voltage-dependent sensitivity to magnesium. NR2A is expressed throughout the brain, including striatum, forbrain, cerebellum (at protein level) brain cortex, piriform cortex, hippocampus, caudate-putamen, dentate gyrus and granule cell layer. It is found at the postsynaptic cell membrane, dendritic spine, synapse, and cytoplasmic vesicle membrane. A variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia are associated with mutations in the NR2A gene.

Our chicken Anti-GluN2A/NR2A glutamate receptor recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N327/95. It detects human, mouse, rabbit, and rat GluN2A/NR2A is purified by affinity chromatography. It works in WB, IHC, ICC, ELISA.

Our chicken Anti-GluN2A/NR2A glutamate receptor recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N327/95. It detects human, mouse, rabbit, and rat GluN2A/NR2A glutamate receptor and is purified by affinity chromatography. It works in WB, IHC, ICC, ELISA.

Glutamate receptor ionotropic, NMDA 2A (GluN2A) (Glutamate [NMDA] receptor subunit epsilon-1) (N-methyl D-aspartate receptor subtype 2A) (NMDAR2A) (NR2A)

Grin2a

Human, Mouse, Rabbit, and Rat

Fusion protein amino acids 75-325 (extracellular N-terminus) of rat NR2A (accession number Q00959) produced recombinantly in E. Coli

GluN2A/NR2A glutamate receptor

N327/95

Unconjugated

WB, IHC, ICC, ELISA

/ /Neurotransmitter Receptors

Primary Antibodies

1 mg/mL

Purified by affinity chromatography

Liquid

7.4

170 kDa

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Shipped on ice packs

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N327/95 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N327/95 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media.

1:500-1:1000

1:500-1:1000

Does not cross-react with GluN2B/NR2B

1:500-1:1000

Each new lot of antibody is quality control tested by Western blot on rat brain membrane fraction and confirmed to stain the expected molecular weight band.

Q00959

IgY

Rat

Quality Control: WB Brain

1:500-1:1000