Anti-GLUT12/SLC2A12 Antibody Picoband® fluoro550 Vervoeging

Solute carrier family 2, facilitated glucose transporter member 12, also known as SLC2A12, is a protein that in humans is encoded by the SLC2A12 gene. SLC2A12 belongs to a family of transporters that catalyze the uptake of sugars through facilitated diffusion. This family of transporters shows conservation of 12 transmembrane helices as well as functionally significant amino acid residues. By genomic sequence analysis, this gene is mapped to chromosome 6q23.2. SLC2A12 was detected in a perinuclear location in MCF7 cells in the absence of insulin; however, SLC2A12 redistributed to the plasma membrane of MCF7 cells grown continuously in the presence of insulin. This gene acts as facilitative glucose transporter.

Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12; SLC2A12; GLUT12, GLUT8

SLC2A12

154091

Q8TD20

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human GLUT12, identical to the related mouse and rat sequences.

Predominantly expressed in skeletal muscle, heart and prostate, with lower levels in brain, placenta and kidney. .

Flow Cytometry

Atherosclerosis, Cancer, Cardiovascular, Diabetes, Diabetes-associated, Energy Metabolism, Energy Transfer Pathways, Heart Disease, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Signal Transduction

Immunogen affinity purified.

Liquid

Facilitative glucose transporter. .

1. Linden, K. C., DeHaan, C. L., Zhang, Y., Glowacka, S., Cox, A. J., Kelly, D. J., Rogers, S.Renal expression and localization of the facilitative glucose transporters GLUT1 and GLUT12 in animal models of hypertension and diabetic nephropathy. Am. J. Physiol. Renal Physiol. 290: F205-F213, 2006. 2. Wood, I. S., Hunter, L., Trayhurn, P. Expression of class III facilitative glucose transporter genes (GLUT-10 and GLUT-12) in mouse and human adipose tissues. Biochem. Biophys. Res. Commun. 308: 43-49, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

66966 MW

No cross reactivity with other proteins.

6

Solute carrier family 2, facilitated glucose transporter member 12

Endomembrane system ; Multi- pass membrane protein . Cytoplasm, perinuclear region . Localizes primarily perinuclear region in the absence of insulin.

Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.

Solute carrier family 2, facilitated glucose transporter member 12

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.