Anti-GNAL Antibody Picoband® fluoro488 Vervoeging

Guanine nucleotide-binding protein G (olf) subunit alpha is a protein that in humans is encoded by the GNAL gene. This gene encodes a stimulatory G protein alpha subunit which mediates odorant signaling in the olfactory epithelium. This protein couples dopamine type 1 receptors and adenosine A2A receptors and is widely expressed in the central nervous system. Mutations in this gene have been associated with dystonia 25 and this gene is located in a susceptibility region for bipolar disorder and schizophrenia. Alternative splicing results in multiple transcript variants.

B-cell differentiation antigen CD72; Lyb-2; CD72; CD72

GNAL

2774

P38405

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human GNAL recombinant protein (Position: R114-H349) .

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Flow Cytometry

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Stem Cells

Immunogen affinity purified.

Liquid

Plays a role in B-cell proliferation and differentiation.

1. Belluscio, L., Gold, G. H., Nemes, A., Axel, R. Mice deficient in G (olf) are anosmic. Neuron 20: 69-81, 1998. 2. Bressman, S. B., Heiman, G. A., Nygaard, T. G., Ozelius, L. J., Hunt, A. L., Brin, M. F., Gordon, M. F., Moskowitz, C. B., de Leon, D., Burke, R. E., Fahn, S., Risch, N. J., Beakefield, X. O., Kramer, P. L. A study of idiopathic torsion dystonia in a non-Jewish family: evidence for genetic heterogeneity. Neurology 44: 283-287, 1994. 3. Buck, L. B. Information coding in the mammalian olfactory system. Cold Spring Harbor Symp. Quant. Biol. 61: 147-155, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

CD72 molecule

Membrane; Single-pass type II membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.