Anti-GOLGA3 Antibody Picoband® fluoro488 Vervoeging

Golgin subfamily A member 3 is a protein that in humans is encoded by the GOLGA3 gene. The Golgi apparatus, which participates in glycosylation and transport of proteins and lipids in the secretory pathway, consists of a series of stacked cisternae (flattened membrane sacs) . Interactions between the Golgi and microtubules are thought to be important for the reorganization of the Golgi after it fragments during mitosis. This gene encodes a member of the golgin family of proteins which are localized to the Golgi. Its encoded protein has been postulated to play a role in nuclear transport and Golgi apparatus localization. Several alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Formin-1; Limb deformity protein homolog; FMN1; FMN, LD

GOLGA3

2802

Q08378

Human

No cross-reactivity with other proteins.

E.coli-derived human GOLGA3 recombinant protein (Position: Q176-K1436) .

Expressed ubiquitously.

Flow Cytometry

Actin Assembly, Actin, etc., Cytoskeleton, Cytoskeleton/ECM, Microfilaments, Signal Transduction

Immunogen affinity purified.

Liquid

Plays a role in the formation of adherens junction and the polymerization of linear actin cables. .

1. Bray, J. D., Chennathukuzhi, V. M., Hecht, N. B. Identification and characterization of cDNAs encoding four novel proteins that interact with translin associated factor-X. Genomics 79: 799-808, 2002. 2. Fritzler, M. J., Hamel, J. C., Ochs, R. L., Chan, E. K. L. Molecular characterization of two human autoantigens: unique cDNAs encoding 95- and 160-kD proteins of a putative family in the Golgi complex. J. Exp. Med. 178: 49-62, 1993. 3. Hicks, S. W., Machamer, C. E. The NH (2) -terminal domain of golgin-160 contains both Golgi and nuclear targeting information. J. Biol. Chem. 277: 35833-35839, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

157578 MW

6

Formin-1

Nucleus . Cytoplasm . Cell junction, adherens junction . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Localization to the adherens junctions is alpha-catenin-dependent. Also localizes to F-actin bundles originating from adherens junctions and to microtubules (By similarity) . .

BAG family molecular chaperone regulator 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.