Anti-GP161 GPR161 Antilichaam

Boster Bio Anti-GP161 GPR161 Antibody catalog # A10567. Tested in WB, ELISA applications. This antibody reacts with Human, Mouse.

G-protein coupled receptor 161; G-protein coupled receptor RE2; GPR161

GPR161

Q8N6U8

Human, Mouse

Synthesized peptide derived from human protein at AA range: 180-260

WB, ELISA

GP161 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/mL

Liquid

Key negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A10567

58559 MW

G-protein coupled receptor 161

Cell projection, cilium membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Mainly localizes to primary cilium in a TULP3 and IFT-A complex-dependent manner. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes and is apparently not degraded (By similarity) . .

G-protein coupled receptor 161

IgG

Liquid form in PBS containing 50% glycerol, and 0.02% sodium azide.