Anti-GP6 Antibody Picoband® 0,00647 Vervoeging

Enables collagen binding activity and collagen receptor activity. Acts upstream of or within collagen-activated tyrosine kinase receptor signaling pathway; peptidyl-tyrosine phosphorylation; and platelet aggregation. Located in cell surface and plasma membrane. Is expressed in bone marrow; femur; liver; and spleen. Human ortholog (s) of this gene implicated in blood platelet disease (multiple) ; coronary artery disease (multiple) ; and type 2 diabetes mellitus. Orthologous to human GP6 (glycoprotein VI platelet) .

GP6; Platelet glycoprotein VI; GPVI; Glycoprotein 6

GP6

243816

P0C191

Mouse

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of mouse GP6. Mouse GP6 shares 75% amino acid (aa) sequence identity with human GP6.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Boilard, E., Nigrovic, P. A., Larabee, K., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold-O'Donnell, E., Farndale, R. W., Ware, J., Lee, D. M. Platelets amplify inflammation in arthritis via collagen-dependent microparticle production. Science 327: 580-583, 2010. 2. Dumont, B., Lasne, D., Rothschild, C., Bouabdelli, M., Ollivier, V., Oudin, C., Ajzenberg, N., Grandchamp, B., Jandrot-Perrus, M. Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood 114: 1900-1903, 2009. 3. zumi, Y., Uchiyama, T., Takayama, H. Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI. Biochem. Biophys. Res. Commun. 277: 27-36, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

35 kDa

6

Glycoprotein 6 platelet

Platelet glycoprotein VI

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.