Anti-GPR50 Antibody Picoband® 31.0550 Vervoeging

G protein-coupled receptor 50 is a protein which in humans is encoded by the GPR50 gene. This gene product belongs to the G-protein coupled receptor 1 family. Even though this protein shares similarity with the melatonin receptors, it does not bind melatonin, however, it inhibits melatonin receptor 1A function through heterodimerization. Polymorphic variants of this gene have been associated with bipolar affective disorder in women.

Protein SOX-15; Protein SOX-12; Protein SOX-20; SOX15; SOX12; SOX20; SOX26; SOX27

GPR50

9248

Q13585

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human GPR50 recombinant protein (Position: K214-S471) .

Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

Flow Cytometry

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Immunogen affinity purified.

Liquid

Binds to the 5'-AACAAT-3' sequence.

1. Gubitz, A. K., Reppert, S. M. Assignment of the melatonin-related receptor to human chromosome X (GPR50) and mouse chromosome X (Gpr50) . Genomics 55: 248-251, 1999. 2. Levoye, A., Dam, J., Ayoub, M. A., Guillaume, J.-L., Couturier, C., Delagrange, P., Jockers, R. The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J. 25: 3012-3023, 2006. 3. Reppert, S. M., Weaver, D. R., Ebisawa, T., Mahle, C. D., Kolakowski, L. F., Jr. Cloning of a melatonin-related receptor from human pituitary. FEBS Lett. 386: 219-224, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49229 MW

6

SRY-box 15

Nucleus.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.