Anti-Granzyme B/GZMB Antibody Picoband®

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are though to protect their host by inducing apoptosis of cells that bear on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Boster Bio Anti-Granzyme B/GZMB Antibody catalog # PA1738. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Granzyme B;3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMB; CGL1, CSPB, CTLA1, GRB

GZMB

3002

P10144

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme B.

WB

Adaptive Immunity, Apoptosis, Cell Biology, Immunology, Innate Immunity, NK Cells, T Cells

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

1. Huang, C., Bi, E., Hu. Y., Deng, W., Tian, Z., Dong, C., Hu, Y., Sun, B.A novel NF-kappa-B binding site controls human granzyme B gene transcription.J. Immun. 176: 4173-4181, 2006. 2. Motyka, B., Korbutt, G., Pinkoski, M. J., Heibein, J. A., Caputo, A., Hobman, M., Barry, M., Shostak, I., Sawchuk, T., Holmes, C. F. B., Gauldie, J., Bleackley, R. C.Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.Cell 103: 491-500, 2000. 3. Winrow, C. J., Pankratz, D. G., Vibat, C. R. T., Bowen, T. J., Callahan, M. A., Warren, A. J., Hilbush, B. S., Wynshaw-Boris, A., Hasel, K. W., Weaver, Z., Lockhart, D. J., Barlow, C.Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.Hum. Molec. Genet. 14: 2671-2684, 2005.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=PA1738

27716 MW

55 kDa

No cross reactivity with other proteins.

Granzyme B

Cytoplasmic granule . Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Belongs to the peptidase S1 family. Granzyme subfamily.

Granzyme B

Rabbit IgG

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.