Anti-Granzyme B/GZMB Antibody Picoband® fluoro647 Vervoeging

Granzyme B is a serine protease that in humans is encoded by the GZMB gene. Granzyme B is expressed by cytotoxic T lymphocytes (CTL) and natural killer (NK) cells. CTL and NK cells share the remarkable ability to recognize specific infected target cells. They are though to protect their host by inducing apoptosis of cells that bear on their surface nonself antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein encoded by this gene is crucial for the rapid induction of target cell apoptosis by CTL in cell-mediated immune response.

Granzyme B;3.4.21.79; C11; CTLA-1; Cathepsin G-like 1; CTSGL1; Cytotoxic T-lymphocyte proteinase 2; Lymphocyte protease; Fragmentin-2; Granzyme-2; Human lymphocyte protein; HLP; SECT; T-cell serine protease 1-3E; GZMB; CGL1, CSPB, CTLA1, GRB

GZMB

3002

P10144

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Granzyme B.

Flow Cytometry

Adaptive Immunity, Apoptosis, Cell Biology, Immunology, Innate Immunity, NK Cells, T Cells

Immunogen affinity purified.

Liquid

This enzyme is necessary for target cell lysis in cell- mediated immune responses. It cleaves after Asp. Seems to be linked to an activation cascade of caspases (aspartate-specific cysteine proteases) responsible for apoptosis execution. Cleaves caspase-3, -7, -9 and 10 to give rise to active enzymes mediating apoptosis.

1. Huang, C., Bi, E., Hu. Y., Deng, W., Tian, Z., Dong, C., Hu, Y., Sun, B.A novel NF-kappa-B binding site controls human granzyme B gene transcription.J. Immun. 176: 4173-4181, 2006. 2. Motyka, B., Korbutt, G., Pinkoski, M. J., Heibein, J. A., Caputo, A., Hobman, M., Barry, M., Shostak, I., Sawchuk, T., Holmes, C. F. B., Gauldie, J., Bleackley, R. C.Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis.Cell 103: 491-500, 2000. 3. Winrow, C. J., Pankratz, D. G., Vibat, C. R. T., Bowen, T. J., Callahan, M. A., Warren, A. J., Hilbush, B. S., Wynshaw-Boris, A., Hasel, K. W., Weaver, Z., Lockhart, D. J., Barlow, C.Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.Hum. Molec. Genet. 14: 2671-2684, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

27716 MW

No cross reactivity with other proteins.

6

Granzyme B

Cytoplasmic granule . Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Belongs to the peptidase S1 family. Granzyme subfamily.

Granzyme B

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.