Anti-GRASP1/GRIPAP1 Antibody Picoband® fluoro647 Vervoeging

GRIP1-associated protein 1 is a protein that in humans is encoded by the GRIPAP1 gene. This gene encodes a guanine nucleotide exchange factor for the Ras family of small G proteins (RasGEF) . The encoded protein interacts in a complex with glutamate receptor interacting protein 1 (GRIP1) and plays a role in the regulation of AMPA receptor function.

Alpha-amylase 1;3.2.1.1;1,4-alpha-D-glucan glucanohydrolase 1; Salivary alpha-amylase; AMY1A; AMY1; AMY1B; AMY1; AMY1C; AMY1

GRIPAP1

56850

Q4V328

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human GRASP1/GRIPAP1 recombinant protein (Position: R42-S841) .

Highly expressed in the kidney, brain and testis and to a lower extent in heart, liver and small intestine. Expressed in the lens, cornea and retina. Strongly expressed in the distal tips of the retinal neuroepithelium that form the iris and ciliary body.

Flow Cytometry

Complement, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Gross, M. B. Personal Communication. Baltimore, Md. 2/17/2015. 2. Hirosawa, M., Nagase, T., Ishikawa, K., Kikuno, R., Nomura, N., Ohara, O. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. DNA Res. 6: 329-336, 1999. 3. Stinton, L. M., Selak, S., Fritzler, M. J. Identification of GRASP-1 as a novel 97 kDa autoantigen localized to endosomes. Clin. Immun. 116: 108-117, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

57768 MW

6

Alpha-amylase 1

Secreted.

Alpha-amylase 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.