Anti-Growth Hormone/GH1 Antibody Picoband® fluoro488 Vervoeging

Growth Hormone (GH) is mapped to 17q22-q24. Human growth hormone has a molecular mass of 22,005 and contains 191 amino acid residues with 2 disulfide bridges. Rat GH shares 98% amino acid sequence homology with mouse. It binds two receptor molecules and thereby induces signal transduction through receptor dimerization. At high concentrations, GH acts as an antagonist because of a large difference in affinities at the respective binding sites.

Somatotropin; Growth hormone; Gh1; Gh

GH1

24391

P01244

Rat

No cross-reactivity with other proteins

E. coli-derived rat GH recombinant protein (Position: F27-F216) .

Expressed in granulosa and cumulus cells. Expressed in hepatocellular carcinoma cells, but not in non- cancerous liver tissue. .

Flow Cytometry

Developmental Biology, Growth Factors/Hormones, Signal Transduction

Immunogen affinity purified.

Liquid

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

1. Niall, H. D.; Hogan, M. L.; Sauer, R.; Rosenblum, I. Y.; Greenwood, F. C. : Sequence of pituitary and placental lactogenic and growth hormones: evolution from a primordial peptide by gene reduplication. Proc. Nat. Acad. Sci. 68: 866-869, 1971. 2. Sundstrom, M.; Lundqvist, T.; Rodin, J.; Giebel, L. B.; Milligan, D.; Norstedt, G. : Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9 angstrom resolution. J. Biol. Chem. 271: 32197-32203, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24656 MW

No cross reactivity with other proteins.

6

Somatotropin

Secreted.

Belongs to the heparin-binding growth factors family.

Somatotropin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.