Anti-Grp75/HSPA9 Antibody Picoband® fluoroc647 Vervoeging

HSPA9 (heat shock 70kDa protein 9 (mortalin) ), also known as GRP75, mot-2, mthsp75, PBP74, HSPA9B, MORTALIN or MORTALIN, PERINUCLEAR, is a highly conserved member of the HSP70 family of proteins. It functions as a chaperone in the mitochondria, cytoplasm, and centrosome. The  HSPA9  gene  is mapped to chromosome 5q31.2 based on an alignment of the  HSPA9  sequence with the genomic sequence. Knockdown of  HSPA9  in erythroid cultures was associated with an increased number of cells in the G0/G1 phase of the cell cycle and accelerated apoptosis. Knockdown of  Hspa9  in mouse bone marrow cells, followed by transplantation into wildtype recipients, also resulted in loss of erythroid cell number. Haploinsufficiency for  HSPA9  may contribute to abnormal hematopoiesis in myelodysplastic syndromes. This protein plays a role in the control of cell proliferation.

Stress-70 protein, mitochondrial;75 kDa glucose-regulated protein; GRP-75; Heat shock 70 kDa protein 9; Mortalin; MOT; Peptide-binding protein 74; PBP74; HSPA9; GRP75, HSPA9B, mt-HSP70

HSPA9

3313

P38646

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Grp75, identical to the related rat and mouse sequences.

Flow Cytometry

Alzheimer's Disease, Cancer, Cell Cycle, Cell Division, Chaperones, Heat Shock Proteins, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes, Protein Trafficking, Signal Transduction, Tumor Biomarkers

Immunogen affinity purified.

Liquid

Implicated in the control of cell proliferation and cellular aging. May also act as a chaperone. .

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

73680 MW

No cross reactivity with other proteins.

6

Stress-70 protein, mitochondrial

Mitochondrion . Nucleus, nucleolus .

Belongs to the heat shock protein 70 family.

Stress-70 protein, mitochondrial

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.