Anti-GSTM2 Antibody Picoband® APC-vervoeging

Cytosolic and membrane-bound forms of glutathione S-transferase are encoded by two distinct supergene families. At present, eight distinct classes of the soluble cytoplasmic mammalian glutathione S-transferases have been identified: alpha, kappa, mu, omega, pi, sigma, theta and zeta. This gene encodes a glutathione S-transferase that belongs to the mu class. The mu class of enzymes functions in the detoxification of electrophilic compounds, including carcinogens, therapeutic drugs, environmental toxins and products of oxidative stress, by conjugation with glutathione. The genes encoding the mu class of enzymes are organized in a gene cluster on chromosome 1p13.3 and are known to be highly polymorphic. These genetic variations can change an individual's susceptibility to carcinogens and toxins as well as affect the toxicity and efficacy of certain drugs.

GSTM2; GST4; Glutathione S-transferase Mu 2; EC 2.5.1.18; GST class-mu 2; GSTM2-2

GSTM2

2946

P28161

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human GSTM2. Mouse GSTM2 shares 72% amino acid (aa) sequence identity with both mouse and rat GSTM2.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Mannervik, B. The isozymes of glutathione transferase. Adv. Enzymol. Relat. Areas Molec. Biol. 57: 357-417, 1985. 2. Pearson, W. R., Vorachek, W. R., Xu, S., Berger, R., Hart, I., Vannais, D., Patterson, D. Identification of class-mu glutathione transferase genes GSTM1-GSTM5 on human chromosome 1p13. Am. J. Hum. Genet. 53: 220-233, 1993. 3. Taylor, J. B., Oliver, J., Sherrington, R., Pemble, S. E. Structure of human glutathione S-transferase class mu genes. Biochem. J. 274: 587-593, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26 kDa

6

Glutathione S-transferase mu 2

Glutathione S-transferase Mu 2

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.