Anti-GTF2F2 Antibody Picoband® fluoro594 Vervoeging

General transcription factor IIF subunit 2 is a protein that in humans is encoded by the GTF2F2 gene. In eukaryotic systems, initiation of transcription from protein-coding genes is a complex process requiring RNA polymerase II and broad families of auxiliary transcription factors. Such factors can be divided into two major functional classes: the basal factors that are required for transcription of all Pol II genes, including TFIIA, TFIIB, TFIID, TFIIE, TFIIF and TFIIH; and sequence-specific factors that regulate gene expression. The basal transcription factors and Pol II form a specific multiprotein complex near the transcription start site by interacting with core promotor elements such as the TATA box generally located 25-30 base pairs upstream of the transcription start site. TFIIF, a heteromer composed of a small (RAP 30) and a large (RAP 74) subunit, is required for RNA polymerase II to assemble into a preinitiation complex formed by promotor DNA and the general factors TFIID, IIA and IIB. In addition, TFIIF stimulates transcription elongation by RNA polymerase II.

Interleukin-17B; IL-17B; Cytokine CX1; Cytokine-like protein ZCYTO7; Neuronal interleukin-17-related factor; Il17b; Nirf, Zcyto7

GTF2F2

2963

P13984

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human GTF2F2 recombinant protein (Position: K13-K226) .

Expressed in adult pancreas, small intestine, stomach, spinal cord and testis. Less pronounced expression in prostate, colon mucosal lining, and ovary.

Flow Cytometry

Cytokines, Immunology, Innate Immunity, Interleukins

Immunogen affinity purified.

Liquid

Stimulates the release of tumor necrosis factor alpha and IL-1-beta from the monocytic cell line THP-1. .

1. Horikoshi, M., Fujita, H., Wang, J., Takada, R., Roeder, R. G. Nucleotide and amino acid sequence of RAP30. Nucleic Acids Res. 19: 5436 only, 1991. 2. Sopta, M., Burton, Z. F., Greenblatt, J. Structure and associated DNA-helicase activity of a general transcription initiation factor that binds to RNA polymerase II. Nature 341: 410-414, 1989. 3. Tan, S., Conaway, R. C., Conaway, J. W. Dissection of transcription factor TFIIF functional domains required for initiation and elongation. Proc. Nat. Acad. Sci. 92: 6042-6046, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Interleukin 17B

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.