Anti-Guanylaatbindend eiwit 1 GBP1 Antilichaampicoband®

Interferons induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs) . GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3. The 593-amino acid GBP1 protein shares 77% and 88% identity with GBP2 and GBP3, respectively. All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T (L/V) RD sequence not found in other GTPases. The GBP1 gene to the GBP gene cluster on chromosome 1p22.2. It is located telomeric to GBP2 and centromeric to GBP3. High expression of GBP1, GBP2, and GBP3 are in endothelial cells after stimulation with IFNG, TNF, or IL1B .

Boster Bio Anti-Guanylate-binding protein 1 GBP1 Antibody catalog # PA1550. Tested in WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Interferon-induced guanylate-binding protein 1; GTP-binding protein 1; GBP-1; HuGBP-1; Guanine nucleotide-binding protein 1; GBP1

GBP1

2633

P32455

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human GBP1.

WB

Signal Transduction

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes. .

1. Cheng, Y.-S. E., Patterson, C. E., Staeheli, P.Interferon-induced guanylate-binding proteins lack an N (T) KXD consensus motif and bind GMP in addition to GDP and GTP.Molec. Cell. Biol. 11: 4717-4725, 1991. 2. Olszewski, M. A., Gray, J., Vestal, D. J.In silico genomic analysis of the human and murine guanylate-binding protein (GBP) gene clusters.J. Interferon Cytokine Res. 26: 328-352, 2006. 3. Tripal, P., Bauer, M., Naschberger, E., Mortinger, T., Hohenadl, C., Cornali, E., Thurau, M., Sturzl, M.Unique features of different members of the human guanylate-binding protein family.J. Interferon Cytokine Res. 27: 44-52, 2007.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=PA1550

67931 MW

68 kDa

No cross reactivity with other proteins.

Interferon-induced guanylate-binding protein 1

Cytoplasm. Golgi apparatus membrane; Lipid- anchor; Cytoplasmic side. Secreted. Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of interferon-gamma induction. Golgi membrane localization requires isoprenylation and the presence of another IFN-gamma-induced factor.

Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3-type GTPase family. GB1 subfamily.

Guanylate-binding protein 1

Rabbit IgG

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.