Anti-GWL/MASTL Antibody Picoband® fluoro488 Vervoeging

This gene encodes a microtubule-associated serine/threonine kinase. Mutations at this locus have been associated with autosomal dominant thrombocytopenia, also known as thrombocytopenia-2. Alternatively spliced transcript variants have been described for this locus.

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1

MASTL

84930

Q96GX5

Human

No cross-reactivity with other proteins.

E.coli-derived human GWL/MASTL recombinant protein (Position: K179-L872) .

Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

1. Di Paola, J., Johnson, J. Thrombocytopenias due to gray platelet syndrome or THC2 mutations. Semin. Thromb. Hemost. 37: 690-697, 2011. 2. Drachman, J. G., Jarvik, G. P., Mehaffey, M. G. Autosomal dominant thrombocytopenia: incomplete megakaryocyte differentiation and linkage to human chromosome 10. Blood 96: 118-125, 2000. 3. Gandhi, M. J., Cummings, C. L., Drachman, J. G. FLJ14813 missense mutation: a candidate for autosomal dominant thrombocytopenia on human chromosome 10. Hum. Hered. 55: 66-70, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Chemokine (C motif) ligand 1

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.