Anti-H2AFY2/MACROH2A2 Antibody Picoband®

Core histone macro-H2A.2 is a protein that in humans is encoded by the H2AFY2 gene. Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4) . The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and may participate in stable X chromosome inactivation.

Boster Bio Anti-H2AFY2/MACROH2A2 Antibody Picoband® catalog # A09931-1. Tested in ELISA, IF, IHC, ICC, WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

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MACROH2A2

55506

Q9P0M6

Human, Mouse, Rat

No cross reactivity with other proteins.

E.coli-derived human H2AFY2/MACROH2A2 recombinant protein (Position: D181-D340) . Human MACROH2A2 shares 99.4% amino acid (aa) sequence identity with mouse MACROH2A2.

Expressed in all tissues.

WB, IHC, ICC, IF, Flow Cytometry, ELISA

Signal Transduction, Signaling Pathway, Small G Proteins

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Chadwick, B. P., Willard, H. F. Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. Hum. Molec. Genet. 10: 1101-1113, 2001. 2. Costanzi, C., Pehrson, J. R. MACROH2A2, a new member of the MACROH2A core histone family. J. Biol. Chem. 276: 21776-21784, 2001. 3. Pehrson, J. R., Changolkar, L. N., Costanzi, C., Leu, N. A. Mice without macroH2A histone variants. Molec. Cell. Biol. 34: 4523-4533, 2014.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A09931-1

52588 MW

40 kDa

6

Serine/threonine-protein kinase AtPK1/AtPK6

Cytoplasm. Nucleus.

Serine/threonine-protein kinase AtPK1/AtPK6

IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.