Anti-HBS1L Antibody Picoband® Biotin Conjugated

This gene encodes a member of the GTP-binding elongation factor family. It is expressed in multiple tissues with the highest expression in heart and skeletal muscle. The intergenic region of this gene and the MYB gene has been identified to be a quantitative trait locus (QTL) controlling fetal hemoglobin level, and this region influnces erythrocyte, platelet, and monocyte counts as well as erythrocyte volume and hemoglobin content. DNA polymorphisms at this region associate with fetal hemoglobin levels and pain crises in sickle cell disease. A single nucleotide polymorphism in exon 1 of this gene is significantly associated with severity in beta-thalassemia/Hemoglobin E. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene.

HBS1L; HBS1; KIAA1038; HBS1-like protein; ERFS

HBS1L

10767

Q9Y450

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human HBS1L recombinant protein (Position: H293-K622) . Human HBS1L shares 96.4% and 97% amino acid (aa) sequence identity with mouse and rat HBS1L, respectively.

WB, IHC, ELISA

Immunogen affinity purified.

Liquid

1. Kikuno, R., Nagase, T., Ishikawa, K., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 6: 197-205, 1999. 2. Wallrapp, C., Verrier, S.-B., Zhouravleva, G., Philippe, H., Philippe, M., Gress, T. M., Jean-Jean, O. The product of the mammalian orthologue of the Saccharomyces cerevisiae HBS1 gene is phylogenetically related to eukaryotic release factor 3 (eRF3) but does not carry eRF3-like activity. FEBS Lett. 440: 387-392, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

75 kDa

HBS1 like translational GTPase

HBS1-like protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.