Anti-HCC1 SARNP Antilichaam

Boster Bio Anti-HCC1 SARNP Antibody (Catalog# A11119) . Tested in WB, IHC, ICC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

SARNP; HCC1; HSPC316; SAP domain-containing ribonucleoprotein; Cytokine-induced protein of 29 kDa; Nuclear protein Hcc-1; Proliferation-associated cytokine-inducible protein CIP29

SARNP

P82979

Human, Mouse, Rat

A peptide derived from human HCC1. Immunogen sequence location: 147-196

Low expression in spleen, liver, pancreas, testis, thymus, heart, and kidney. Increased levels are seen in hepatocellular carcinoma and pancreatic adenocarcinoma.

WB, IHC, ICC, IF, ELISA

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

The antibody was purified from rabbit antiserum by affinity-chromatography using immunogen.

0.5-1mg/mL, actual concentration vary by lot. Use suggested dilution ratio to decide dilution procedure.

Liquid

Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single- stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.

Store at -20°C for one year. For short-term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A11119

23671 MW

SAP domain-containing ribonucleoprotein

Nucleus. Nucleus speckle.

Rabbit IgG

PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.