Anti-HDAC2/Histone Deacetylase 2 Konijn Monoklonale Antilichaam

Boster Bio Anti-HDAC2/Histone Deacetylase 2 Rabbit Monoclonal Antibody catalog # M00325. Tested in WB, IP applications. This antibody reacts with Human, Mouse, Rat.

Histone deacetylase 2; HD2;3.5.1.98; HDAC2

HDAC2

3066

Q92769

Human, Mouse, Rat

A synthesized peptide derived from human HDAC2

Clone: HED-8

Widely expressed; lower levels in brain and lung.

WB, IP

Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Class I, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells

Affinity-chromatography

0.5mg/ml

Liquid

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed of DNMT1, DMAP1, PCNA, CAF1. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. May be involved in the transcriptional repression of circadian target genes, such as PER1, mediated by CRY1 through histone deacetylation. Involved in MTA1-mediated transcriptional corepression of TFF1 and CDKN1A. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00325

55364 MW

47 kDa

Histone deacetylase 2

Nucleus . Cytoplasm .

P2X purinoceptor 1

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.