Anti-HDAC3 Konijn Monoklonale Antilichaam

Boster Bio Anti-HDAC3 Rabbit Monoclonal Antibody catalog # M00839. Tested in WB, IHC, ICC/IF, IP applications. This antibody reacts with Human, Mouse, Rat.

Histone deacetylase 3; HD3;3.5.1.98; RPD3-2; SMAP45; HDAC3

HDAC3

8841

O15379

Human, Mouse, Rat

A synthesized peptide derived from human HDAC3

Clone: EFH-8

Widely expressed.

WB, IHC, ICC, IF, IP

Acetylation, Cancer, Cancer Metabolism, Cardiovascular, Chromatin Modifying Enzymes, Class I, Epigenetics and Nuclear Signaling, Hypertrophy, Lipid and Lipoprotein Metabolism, Lipid Metabolism, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism of Lipids and Lipoproteins, Oncoproteins/Suppressors, Pathways and Processes, Signaling Pathways, Stem Cells, Tumor Suppressors

Affinity-chromatography

0.5mg/ml

Liquid

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys- 27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 repression activity. Required to repress transcription of the POU1F1 transcription factor. Acts as a molecular chaperone for shuttling phosphorylated NR2C1 to PML bodies for sumoylation (PubMed:21444723, PubMed:23911289) . Contributes, together with XBP1 isoform 1, to the activation of NFE2L2-mediated HMOX1 transcription factor gene expression in a PI (3) K/mTORC2/Akt-dependent signaling pathway leading to endothelial cell (EC) survival under disturbed flow/oxidative stress (PubMed:25190803) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00839

48848 MW

49 kDa

Histone deacetylase 3

Nucleus . Cytoplasm . Cytoplasm, cytosol . Colocalizes with XBP1 and AKT1 in the cytoplasm (PubMed:25190803) . Predominantly expressed in the nucleus in the presence of CCAR2. .

Glycogen synthase kinase-3 beta (gsk3b)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.