Anti-HDAC4/Histone Deacetylase 4 Konijn Monoklonale Antilichaam

Boster Bio Anti-HDAC4/Histone Deacetylase 4 Rabbit Monoclonal Antibody catalog # M00971. Tested in WB, ICC/IF applications. This antibody reacts with Human.

Histone deacetylase 4; HD4;3.5.1.98; HDAC4; KIAA0288

HDAC4

9759

P56524

Human

A synthesized peptide derived from human HDAC4

Clone: HGI-8

Ubiquitous.

WB, ICC, IF

Acetylation, Cardiovascular, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells

Affinity-chromatography

0.5mg/ml

Liquid

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00971

119040 MW

180-230 kDa

Histone deacetylase 4

Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. Upon muscle cells differentiation, it accumulates in the nuclei of myotubes, suggesting a positive role of nuclear HDAC4 in muscle differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-246, Ser-467 and Ser-632 by CaMK4 and SIK1. The nuclear localization probably depends on sumoylation.

Glycogen synthase kinase-3 beta (gsk3b)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.