Anti-HDAC7/Histone Deacetylase 7 Konijn Monoklonale Antilichaam

Boster Bio Anti-HDAC7/Histone Deacetylase 7 Rabbit Monoclonal Antibody catalog # M01913. Tested in WB, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Histone deacetylase 7; HD7;3.5.1.98; Histone deacetylase 7A; HD7a; HDAC7; HDAC7A

HDAC7

51564

Q8WUI4

Human, Mouse, Rat

A synthesized peptide derived from human HDAC7

Clone: HFG-8

Ubiquitous.

WB, Flow Cytometry

Cardiovascular, Chromatin Modifying Enzymes, Epigenetics and Nuclear Signaling, Hypertrophy, Signaling Pathways, Stem Cells

Affinity-chromatography

0.5mg/ml

Liquid

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer factors such as MEF2A, MEF2B and MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors (By similarity) . May be involved in Epstein-Barr virus (EBV) latency, possibly by repressing the viral BZLF1 gene. Positively regulates the transcriptional repressor activity of FOXP3 (PubMed:17360565) . .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M01913

102927 MW

50 kDa

Histone deacetylase 7

Nucleus. Cytoplasm. In the nucleus, it associates with distinct subnuclear dot-like structures. Shuttles between the nucleus and the cytoplasm. Treatment with EDN1 results in shuttling from the nucleus to the perinuclear region. The export to cytoplasm depends on the interaction with the 14-3-3 protein YWHAE and is due to its phosphorylation.

Lysosome-associated membrane glycoprotein 2 (Lamp2)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.